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Does the Interaction Between Alcohol Use and Depression Exacerbate Hyperglycemia Risk? A Cross-Sectional Study Beyond
Simona-Dana Mitincu-Caramfil1,2, Anca Pantea Stoian3, Lavinia-Alexandra Moroianu1
1Pharmaceutical Sciences Department, Faculty of Medicine and Pharmacy, "Dunărea de Jos" University, 800201 Galaţi, Romania.
Medicina (Kaunas, Lithuania)
|August 28, 2025
Summary
Heavy alcohol use and severe depression significantly increase hyperglycemia risk in psychiatric patients. Combined, these conditions lead to a 95.8% prevalence of hyperglycemia, underscoring the need for integrated care.
Area of Science:
- Psychiatry
- Endocrinology
- Public Health
Background:
- Psychiatric patients often exhibit co-occurring conditions like heavy alcohol use and depression.
- Hyperglycemia is a significant health concern, particularly within vulnerable patient populations.
- The synergistic impact of alcohol and depression on metabolic health in psychiatric settings requires investigation.
Purpose of the Study:
- To investigate the interaction between heavy alcohol use and depression in amplifying hyperglycemia risk among psychiatric patients.
- To quantify the combined effect of alcohol consumption and depressive symptoms on blood glucose levels.
- To identify specific risk profiles for hyperglycemia in a hospitalized psychiatric cohort.
Main Methods:
- Cross-sectional study of 172 psychiatric patients (aged 18-65) in Romania.
- Data collection included fasting blood glucose, GGT, Beck Depression Inventory (BDI), and Alcohol Use Disorders Identification Test (AUDIT) scores.
- Statistical analyses employed multiple and logistic regression to assess the interaction between BDI and AUDIT scores on hyperglycemia.
Main Results:
- Moderate positive correlations were found between depression scores and blood glucose (r=0.44) and alcohol consumption and blood glucose (r=0.43).
- The interaction term (BDI × AUDIT) was a significant predictor of glucose variability (β=0.012, p=0.001).
- Hyperglycemia prevalence was 95.8% in patients with both high alcohol use and severe depression, with a significant interaction effect (OR=19.3, p=0.001).
Conclusions:
- The combined presence of heavy alcohol use and severe depression significantly elevates the risk of hyperglycemia in psychiatric patients.
- Neither condition alone was a significant predictor, but their interaction dramatically increased hyperglycemia risk.
- Integrated screening and interventions for alcohol use and depression are crucial in psychiatric care to mitigate hyperglycemia.
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