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Supramarginal Resection of Metastatic Brain Tumors: A Meta-Analysis Study
Florin Adrian Tofan1, Ahmed T Massoud2, Cosmin Ioan Faur3
1Department of Neurosurgery, Faculty of Medicine, University of Medicine and Pharmacy Iuliu Hatieganu, 400012 Cluj Napoca, Romania.
Medicina (Kaunas, Lithuania)
|August 28, 2025
Summary
Supramarginal resection shows superior outcomes for brain metastases compared to gross total resection (GTR). This approach significantly improves survival rates and reduces local recurrence, offering a promising alternative for cancer patients.
Area of Science:
- Neurosurgery
- Oncology
- Medical Research
Background:
- Brain metastases affect over 30% of cancer patients.
- Gross total resection (GTR) is standard but may be insufficient due to residual tumor invasion.
- Current data on GTR versus supramarginal resection for brain metastases needs comprehensive comparison.
Purpose of the Study:
- To compare the outcomes of gross total resection (GTR) and supramarginal resection for brain metastases.
- To summarize current data on surgical management of brain metastases.
- To evaluate survival rates and local recurrence incidence for both resection types.
Main Methods:
- Systematic literature search of PubMed, Scopus, Cochrane, and Web of Science.
- Inclusion criteria: patients with single or multiple brain metastases of any origin.
- Comparison of outcomes between patients undergoing GTR and supramarginal resection.
Main Results:
- Supramarginal resection group showed significantly higher 1-year (91.3%) and 2-year (72.46%) survival rates compared to GTR (37.1% and 21.26%, respectively).
- Local recurrence incidence was substantially lower in the supramarginal resection group (18.4%) versus the GTR group (57.69%).
- Average patient age ranged from 51 to 60.5 years, with 48.7% males.
Conclusions:
- Supramarginal resection demonstrates superior efficacy in managing brain metastases.
- This approach offers improved survival and reduced recurrence rates.
- Supramarginal resection presents a promising alternative surgical strategy for brain metastases.
