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Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
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Test-Retest Reliability and Inter-Scanner Reproducibility of Improved Spinal Diffusion Tensor Imaging.

Christer Ruff1, Stephan König1, Tim W Rattay2

  • 1Department of Diagnostic and Interventional Neuroradiology, Eberhard Karls-University Tuebingen, 72076 Tuebingen, Germany.

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Summary
This summary is machine-generated.

An optimized spinal diffusion tensor imaging (sDTI) protocol provides reproducible fractional anisotropy (FA) measurements for spinal cord tracts, showing scanner independence. This robust tool aids in detecting and monitoring spinal cord pathologies.

Keywords:
fractional anisotropymean diffusivityradial diffusivityspinal diffusion tensor imaging

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Area of Science:

  • Neuroimaging
  • Radiology
  • Biomedical Engineering

Background:

  • Spinal diffusion tensor imaging (sDTI) faces challenges in selectively evaluating key spinal cord structures like pyramidal tracts (PTs) and dorsal columns (DCs).
  • Reliable quantification of diffusion metrics (FA, RD, MD, AD) in the spinal cord is crucial but difficult with current sDTI methods.

Purpose of the Study:

  • To assess the reproducibility, robustness, and reliability of an optimized axial sDTI protocol for long fiber tracts in the cervical spinal cord.
  • To evaluate the performance of the optimized protocol across different 3.0 T scanners.

Main Methods:

  • Developed an optimized Stejskal-Tanner sequence for high-resolution axial sDTI of the cervical spinal cord at 3.0 T.
  • Estimated DTI values for PTs, DCs, and anterior horns (AHs) in 16 healthy volunteers.
  • Evaluated reliability using repeated measurements, inter-scanner comparisons, paired t-tests, ICCs, Bland-Altman analysis, and CVs.

Main Results:

  • The optimized sDTI protocol demonstrated high consistency and reproducibility for fractional anisotropy (FA) measurements between test-retest sessions and across scanners (Skyra and Prisma).
  • Fractional anisotropy (FA) coefficients of variation (CVs) were consistently low (<10%) across all evaluated regions and scanners.
  • Radial diffusivity (RD) showed good-to-excellent ICC values but higher CVs (14.6-19.4%) for PTs and DCs.

Conclusions:

  • The improved sDTI protocol offers highly reproducible FA measurements, demonstrating scanner independence.
  • This optimized sDTI approach is a robust tool with potential for detecting and monitoring spinal cord pathologies.
  • Further investigation into RD reproducibility may be warranted for comprehensive spinal cord assessment.