Related Experiment Video

Updated: May 2, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

15.0K

Micro and Nano Drug Delivery Systems for the Treatment of Oral Mucositis: A Review

Luciana Ângela Soares Maia1, Tâmara Thaiane Almeida Siqueira1, Carlos Alberto Arcelly Santos Bezerra1

  • 1Laboratory of Synthesis and Drug Delivery, Paraiba State University, Rua Horácio Trajano de Oliveira, s/n, Cristo Redentor, João Pessoa 58075-540, PB, Brazil.

Pharmaceutics
|August 28, 2025
PubMed

Insights

Nanobased drug delivery systems show promise for treating oral mucositis (OM), a common side effect of cancer therapy. These advanced systems offer improved outcomes compared to traditional methods, though further clinical trials are needed.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmacology

Background:

  • Oral mucositis (OM) is a debilitating inflammatory condition of the oral mucosa, frequently linked to cancer therapies.
  • Current treatments for OM often exhibit limited effectiveness and considerable adverse effects, driving the need for novel therapeutic strategies.

Purpose of the Study:

  • To systematically review and evaluate the efficacy of nanobased drug delivery systems (DDSs) for the treatment of oral mucositis.
  • To assess the current landscape of research, including in vitro, in vivo, and clinical studies, on nanobased DDSs for OM.

Main Methods:

  • An extensive literature search was performed across BVS, PubMed, Scopus, and Web of Science databases.
  • Keywords included "microparticles," "nanoparticles," "drug delivery system," "oral mucositis," "therapy," and "treatment," combined with Boolean operators.
  • A total of 32 relevant articles were selected after applying filters and removing duplicates.

Main Results:

  • A significant majority of the reviewed studies (25 out of 32) utilized polymeric micro- or nanosystems for OM treatment.
  • The analysis encompassed 10 in vitro studies, 16 in vivo studies, and 6 clinical trials.
  • Most studies reported superior therapeutic outcomes with nanobased DDSs compared to conventional drug delivery methods.

Conclusions:

  • Nanobased DDSs represent a promising innovative approach for enhancing the treatment of oral mucositis.
  • Challenges related to large-scale manufacturing, reproducibility, and safety require careful consideration.
  • Further extensive clinical trials are crucial to validate these findings and inform clinical practice.
Keywords:
dosage formdrug deliverymicrosystemsnanosystemsoral mucositistreatment

More Related Videos

Retroductal Nanoparticle Injection to the Murine Submandibular Gland07:45

Retroductal Nanoparticle Injection to the Murine Submandibular Gland

Published on: May 3, 2018

10.2K
Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis07:05

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Published on: May 12, 2019

5.9K

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.9K
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
406
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
164
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
279
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
308
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
222