Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Crocin alleviates "short-term" Cadmium-induced brain and lung toxicities: investigation of key neuropeptides GLP-1 and spexin as biomarkers.

Metabolic brain disease·2026
Same author

Corrigendum to "Osteogenic enhancement of modular ceramic nanocomposites impregnated with human dental pulp stem cells: an approach for bone repair and regenerative medicine" [J. Genet. Eng. Biotechnol. 20(1) (2022) 123].

Journal, genetic engineering & biotechnology·2026
Same author

Exploring the protective potential of berberine against cardiotoxicity and hepatorenal toxicity in rats.

3 Biotech·2026
Same author

Synthesis, characterization, and antitumor potency of Pd<sup>2+</sup>, ZrO<sup>2+</sup>, and VO<sup>2+</sup> complexes with tridentate Schiff base: in vitro biological and in-silico insights.

BMC chemistry·2026
Same author

Comparative effects of intranasal and intraperitoneal resveratrol on the eye-brain axis in a cisplatin-induced neurotoxic rat model.

Scientific reports·2026
Same author

Biosensor-Integrated Microneedle Devices for Diagnosis and Treatment of Chronic and Infectious Diseases: Current Status, Trends and Challenges.

Biosensors·2026

Related Experiment Video

Updated: Sep 9, 2025

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.2K

Palladium Complex-Loaded Magnetite Nanoparticles as Drug Delivery Systems for Targeted Liver Cancer Therapy.

Sara A M El-Sayed1, Ghadha Ibrahim Fouad2, Hanan H Beherei1

  • 1Refractories, Ceramics and Building Materials Department, National Research Centre, 33 El-Bohouth St. (Former EL Tahrir St.), Dokki, Giza P.O. Box 12622, Egypt.

Pharmaceutics
|August 28, 2025
PubMed
Summary

This study developed a palladium complex loaded onto magnetite nanoparticles (MNPs) for targeted liver cancer treatment. The nano-system showed potent anticancer activity in rats, improving liver health and reducing inflammation.

Keywords:
anticancer selectivitydiethylnitrosamineinflammationliver cancermagnetitemetal/ligand complexmolecular docking simulationthioacetamide

More Related Videos

Biofunctionalization of Magnetic Nanomaterials
06:40

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

2.7K
Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters
09:43

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters

Published on: August 22, 2014

15.4K

Related Experiment Videos

Last Updated: Sep 9, 2025

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.2K
Biofunctionalization of Magnetic Nanomaterials
06:40

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

2.7K
Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters
09:43

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters

Published on: August 22, 2014

15.4K

Area of Science:

  • Nanotechnology
  • Materials Science
  • Oncology

Background:

  • Liver cancer poses significant challenges due to diagnostic delays and limitations of current metal/ligand antitumor drugs, including lack of specificity and damage to healthy organs.
  • Magnetite nanoparticles (MNPs) offer potential for targeted cancer therapy, improving specificity and reducing side effects.
  • There is a critical need for advanced drug delivery systems to enhance the efficacy and safety of liver cancer treatments.

Purpose of the Study:

  • To prepare and characterize a novel nano-system for liver cancer treatment by loading a palladium complex onto magnetite nanoparticles.
  • To evaluate the antitumor activity, drug release profile, and specificity of the palladium-loaded MNPs.
  • To investigate the therapeutic potential of this nano-system in a rat model of liver cancer.

Main Methods:

  • Synthesis and characterization of palladium complex-loaded magnetite nanoparticles using FTIR and TEM.
  • Density Functional Theory (DFT) and molecular docking simulations for structural analysis.
  • In vitro drug release studies at varying pH levels (e.g., pH 4.5) and in vivo evaluation in a diethylnitrosamine/thioacetamide-induced rat liver cancer model.

Main Results:

  • Magnetite nanoparticles with superparamagnetic properties and a large surface area were successfully synthesized, suitable for drug delivery.
  • The palladium complex loaded onto MNPs demonstrated enhanced release in acidic conditions (pH 4.5), indicating potential for targeted liver cancer therapy.
  • In vivo studies showed significant therapeutic efficacy, with the nano-system improving liver function and structure and reducing inflammation in rats.

Conclusions:

  • The developed palladium complex-loaded magnetite nanoparticles exhibit potent anticancer therapeutic activity against liver cancer in a rat model.
  • This nano-system demonstrates potential for targeted drug delivery, improving liver function and mitigating inflammation.
  • The findings support the use of functionalized magnetic nanoparticles as a promising strategy for enhancing liver cancer treatment efficacy and safety.