Sublingual and Buccal Delivery: A Historical and Scientific Prescriptive
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View abstract on PubMed
Summary
This summary is machine-generated.Sublingual and buccal drug delivery has evolved significantly over 75 years, with four distinct growth periods. Research now focuses on advanced mucosal delivery for enhanced therapeutic benefits.
Area Of Science
- Pharmacology and Pharmaceutics
- Drug Delivery Systems
- Mucosal Drug Delivery
Background
- Sublingual and buccal drug delivery routes have been explored for over 75 years.
- Early research (1950-1982) showed limited exploration of these mucosal routes.
- Significant advancements have occurred, particularly since the 1980s.
Purpose Of The Study
- To review the historical development of sublingual and buccal drug delivery over the past 75 years.
- To identify key phases and innovations in this field.
- To highlight the growing research focus on mucosal drug delivery.
Main Methods
- Literature review based on the query "sublingual and buccal".
- Analysis of publication trends from 1950 to 2025.
- Categorization of research into distinct growth periods.
Main Results
- Identified four distinct growth periods in sublingual and buccal delivery research: Early (1950-1982), Exploratory (1983-1993), Diversification (1994-2009), and Innovation (2010-2025).
- Documented the expansion of therapeutic agents and formulation technologies, including nanoparticles, mucoadhesive systems, and pediatric formulations.
- Noted the increasing use for various conditions, from angina and hypertension to pain management, opioid use disorder, and vaccine delivery.
Conclusions
- Sublingual and buccal drug delivery represents a dynamic and expanding area of pharmaceutical research.
- Historical analysis reveals a continuous innovation trajectory, driven by the need for improved drug efficacy and patient compliance.
- Future research is poised to further enhance mucosal drug delivery for both local and systemic therapeutic outcomes.
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