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A Single-Center Retrospective Study on Early Treatment for COVID-19 in Solid Organ Transplant Recipients During the Omicron Era: Outcomes and SARS-CoV-2 Viral Kinetics

  • 0Infectious Diseases and Hepatology Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.
Microorganisms +

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August 28, 2025

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August 28, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Early COVID-19 treatment in solid organ transplant recipients (SOTRs) is safe and effective, reducing hospitalization rates. Vaccination-induced antibody levels correlate with faster viral load reduction during treatment for these high-risk patients.

Area Of Science

  • Immunology
  • Virology
  • Transplant Medicine

Background

  • Solid organ transplant recipients (SOTRs) face severe COVID-19 risks, necessitating early intervention.
  • Effectiveness of early COVID-19 treatment in SOTRs is unclear due to new SARS-CoV-2 variants and vaccination.

Purpose Of The Study

  • To evaluate the outcomes, safety, and viral load kinetics of early COVID-19 treatment in SOTRs.
  • To assess the impact of early therapy on clinical events and viral load reduction.

Main Methods

  • Retrospective study of 80 SOTRs with symptomatic SARS-CoV-2 infection treated between January-October 2022.
  • Treatment included monoclonal antibodies or antivirals; viral load measured at baseline and day 7.
  • Clinical events (hospitalization, ICU admission, death) assessed within 30 days.

Main Results

  • Low hospitalization rate (2.5%) and no deaths occurred; all treatments were safe.
  • Median viral load decrease was 0.48 log2 ct, with no difference between treatment types.
  • Viral load reduction correlated with anti-spike antibody levels, shorter time to treatment, and fewer comorbidities.

Conclusions

  • Early COVID-19 therapy is effective and safe in SOTRs.
  • Humoral response from vaccination enhances early viral load decay during treatment.
  • Factors like antibody levels and comorbidities influence treatment effectiveness.

Keywords:

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