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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Cyclodextrin/PVP-Based Nanofibers with Rhadiola rosea Extract as a New System for Increasing Bioavailability of
Maciej Jaskólski1, Magdalena Paczkowska-Walendowska1, Zuzanna Rybarczyk1
1Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.
Molecules (Basel, Switzerland)
|August 28, 2025
Summary
Electrospun nanofibers enhanced Rhodiola rosea extract delivery, improving bioavailability of salidroside and rosarin. These cyclodextrin-PVP systems show promise for delivering Rhodiola rosea bioactives.
Area of Science:
- Pharmacology
- Materials Science
- Biotechnology
Background:
- Rhodiola rosea contains bioactive compounds like salidroside and rosarin.
- Enhancing the bioavailability of these compounds is crucial for therapeutic efficacy.
- Electrospun nanofibers offer a novel drug delivery system.
Purpose of the Study:
- To optimize Rhodiola rosea extraction.
- To develop and optimize electrospun nanofiber systems for enhanced bioavailability of salidroside and rosarin.
- To evaluate the functional and technological properties of these systems.
Main Methods:
- Design of Experiments (DoE) for nanofiber formulation.
- Preparation of nanofibers using polyvinylpyrrolidone (PVP) and hydroxypropyl-cyclodextrins (HPαCD, HPβCD, HPγCD).
- Comprehensive characterization including morphology, active compound content, dissolution, permeability, mucoadhesion, antioxidant, and anti-inflammatory assays. Principal Component Analysis (PCA) was used.
Main Results:
- Nanofiber formulations significantly improved salidroside and rosarin dissolution and permeability.
- Enhanced antioxidant properties were observed.
- The formulation with 3g HPβCD and 2.5g PVP showed optimal functional and technological properties.
- PCA confirmed composition-dependent bioactivity and properties.
Conclusions:
- Electrospun nanofibers based on cyclodextrin-PVP matrices are a promising strategy for improving Rhodiola rosea bioactive delivery.
- This approach enhances the bioavailability and bioactivity of key compounds.
- Further preclinical studies are warranted.
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