Mortality Risk of Sarcopenia and Malnutrition in Older Patients with Type 2 Diabetes Mellitus
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View abstract on PubMed
Summary
This summary is machine-generated.Nutritional risk and sarcopenia significantly increase mortality in older adults with type 2 diabetes. Focusing on malnutrition is crucial, as sarcopenia
Area Of Science
- Gerontology
- Endocrinology
- Clinical Nutrition
Background
- Type 2 diabetes mellitus (T2DM) is associated with increased mortality risk.
- Sarcopenia and nutritional risk are common in older adults and can exacerbate T2DM complications.
Purpose Of The Study
- To investigate the combined impact of sarcopenia and nutritional risk on all-cause mortality in older individuals with T2DM.
- To stratify mortality risk based on the presence or absence of sarcopenia and nutritional risk.
Main Methods
- A cohort of 396 older adults with T2DM was assessed for sarcopenia using Asian Working Group for Sarcopenia (AWGS) criteria and nutritional risk via Geriatric Nutritional Risk Index (GNRI).
- Participants were categorized into four groups: no nutritional risk/no sarcopenia, nutritional risk/no sarcopenia, no nutritional risk/sarcopenia, and nutritional risk/sarcopenia.
- Time-to-event analysis using Cox regression was employed to assess mortality risk over a median follow-up of 86 months.
Main Results
- A total of 31 deaths occurred during the follow-up period.
- Compared to individuals with no nutritional risk and no sarcopenia, those with nutritional risk and/or sarcopenia exhibited significantly higher mortality hazard ratios (HRs).
- The highest mortality risk was observed in the group with both nutritional risk and sarcopenia (HR=14.0), followed by groups with either nutritional risk (HR=9.08) or sarcopenia (HR=9.08).
Conclusions
- The coexistence of nutritional risk and sarcopenia significantly elevates all-cause mortality risk in older adults with T2DM.
- While sarcopenia alone increased mortality, its impact was not significantly different when combined with nutritional risk compared to nutritional risk alone.
- These findings underscore the critical importance of addressing malnutrition in this patient population.
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