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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
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Helicobacter pylori and Compositional Patterns of Digestive Tract Microbiome in Children: A Literature Review

Ancuta Lupu1, Anca Adam-Raileanu1, Laura Iulia Bozomitu1

  • 1Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

Nutrients
|August 28, 2025
PubMed

Insights

Helicobacter pylori (H. pylori) infection impacts the human microbiome globally. Research suggests H. pylori and its treatments alter gut bacteria in children and adults, paving the way for personalized medicine.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Human Microbiome Research

Background:

  • Helicobacter pylori (H. pylori) is a prevalent global pathogen affecting over half the world's population.
  • Despite extensive research, the intricate relationship between H. pylori and the human host remains incompletely understood.
  • H. pylori infection, particularly acquired in childhood, has significant implications for human health.

Purpose of the Study:

  • To review the current understanding of H. pylori's interaction with the human microbiome.
  • To investigate the impact of H. pylori presence and eradication on the composition of bacterial communities.
  • To explore the potential for personalized medicine approaches based on microbiota modulation.

Main Methods:

  • A comprehensive literature review was performed.
  • Searches were conducted in major scientific databases: PubMed/Medline, Web of Science, and EMBASE.
  • Studies focusing on H. pylori and human microbiota reports were included.

Main Results:

  • The precise nature of the H. pylori-human microbiome relationship is still unclear.
  • Both H. pylori infection and its eradication treatments demonstrably alter bacterial community composition.
  • These alterations are observed throughout the digestive tract in both pediatric and adult populations.

Conclusions:

  • Understanding microbiota composition is crucial for advancing personalized medicine strategies.
  • While pediatric research is limited, adult study findings support further investigation into microbiota manipulation in children.
  • Targeting microbiota modulation holds promise for beneficial health outcomes in H. pylori-affected individuals.

Keywords:
Helicobacter pylorichildrendigestive tractmicrobiota

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