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Triaxial compression of "cappable" formulations.

J T Carstensen, G J Alcorn, S A Hussain

    Journal of Pharmaceutical Sciences
    |November 1, 1985
    PubMed
    Summary
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    Tablet capping, a visible lamination issue, occurs during uniaxial relaxation. This study introduces a novel triaxial method to release stress in tablets, preventing capping defects.

    Area of Science:

    • Pharmaceutical sciences
    • Materials science

    Background:

    • Tablet capping, characterized by visible lamination, is a common manufacturing defect.
    • It is theorized to occur during the uniaxial relaxation stage when upper punch pressure is released.

    Purpose of the Study:

    • To investigate the phenomenon of tablet capping.
    • To introduce and describe a novel method for mitigating tablet capping.

    Main Methods:

    • The study describes a method to release stress in tablets prone to capping.
    • This method involves a triaxial stress release mechanism.

    Main Results:

    • The described triaxial method effectively addresses stress buildup in tablets.
    • This approach aims to prevent the occurrence of capping defects.

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    Conclusions:

    • The triaxial stress release method offers a potential solution to tablet capping.
    • This technique may improve tablet quality and manufacturing consistency.