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Updated: Sep 9, 2025

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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
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Recent Developments in Microneedle Biosensors for Biomedical and Agricultural Applications
Kazim Haider1, Colin Dalton1,2
1Department of Biomedical Engineering, University of Calgary, Calgary, AB T2N 1N4, Canada.
Micromachines
|August 28, 2025
Summary
Microneedle biosensors show promise in medicine and agriculture. Future research should address challenges like biofouling and electrode degradation for improved long-term monitoring.
Area of Science:
- Biosensing technologies
- Biomedical engineering
- Agricultural science
Background:
- Microneedles are versatile tools for biosensing in medicine and agriculture.
- Recent advancements focus on novel applications beyond traditional uses.
Purpose of the Study:
- To review recent progress in microneedle-based biosensors in emerging fields.
- To identify key challenges and future research opportunities.
Main Methods:
- Literature review of recent advancements in microneedle biosensor technology.
- Analysis of applications in biomedical and agricultural domains.
- Identification of persistent challenges and future research directions.
Main Results:
- Microneedle biosensors are advancing in continuous glucose monitoring and multiplexed biomarker detection.
- Integrated wearable systems with microneedle arrays are increasingly common.
- Agricultural applications include monitoring plant growth markers, hormones, and nutrients.
- Challenges include biofouling, electrode degradation, and scalability of fabrication.
Conclusions:
- Further research is needed to overcome biofouling and electrode degradation for long-term in situ monitoring.
- Standardized testing protocols and performance metrics are required for accurate comparisons.
- Opportunities exist for developing scalable fabrication processes and improving electrode longevity.
Keywords:
biosensorselectrochemical sensinginterstitial fluid (ISF) sensingmicroneedlesmulti-analyte detectionpoint-of-care diagnosticssmart agriculture
