Chlorambucil in the treatment of intractable Uveitis associated with juvenile chronic arthritis

The response to prolonged low dose chlorambucil for chronic active uveitis in 6 patients with juvenile chronic arthritis and one patient with juvenile ankylosing spondylitis is described. Only 2 patients were judged to have had longterm benefit from treatment in both eyes and one had a transient benefit in one eye. Drug induced adverse effects occurred in 3 patients.