Related Experiment Video
Updated: Sep 9, 2025
03:38
Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
Published on: June 20, 2025
322
Breathless Aftermath: Post-COVID-19 Pulmonary Fibrosis
Dharanya Muthiah1,2, Kishore Vaddadi1,2, Lin Liu1,2
1Oklahoma Center for Respiratory and Infectious Diseases, Oklahoma State University, Stillwater, OK 74074, USA.
Viruses
|August 28, 2025
Summary
Long COVID can cause persistent lung scarring, known as post-COVID-19 pulmonary fibrosis. This review explores its mechanisms, diagnosis, and potential treatments for better patient outcomes.
Area of Science:
- Pulmonology
- Infectious Diseases
- Pathology
Background:
- Post-Acute Sequelae of SARS-CoV-2 infection (PASC), or long COVID, affects many individuals post-recovery.
- Post-COVID-19 pulmonary fibrosis (PC19-PF) is a severe long COVID complication causing progressive lung scarring and chronic respiratory issues.
- The pathogenesis of PC19-PF is not well understood, hindering effective treatment development.
Purpose of the Study:
- To provide a comprehensive review of post-COVID-19 pulmonary fibrosis (PC19-PF).
- To elucidate the epidemiology, clinical features, diagnostic methods, and underlying mechanisms of PC19-PF.
- To explore shared pathways with other fibrotic lung diseases and discuss emerging therapeutic strategies.
Main Methods:
- Literature review of clinical and experimental studies on PC19-PF.
- Analysis of epidemiological data and clinical manifestations.
- Synthesis of mechanistic insights and therapeutic approaches.
Main Results:
- PC19-PF presents as progressive lung scarring, leading to chronic respiratory impairment.
- Understanding shared fibrotic pathways may offer novel therapeutic targets.
- Emerging strategies aim to address the underlying mechanisms of PC19-PF.
Conclusions:
- PC19-PF is a significant and severe long-term complication of COVID-19.
- Further research into PC19-PF pathogenesis is crucial for developing effective treatments.
- Consolidating current knowledge can guide the development of mechanism-based therapies for lung fibrosis.
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