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The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
Published on: August 5, 2017
Altered neuronal network connectivity in children with fetal alcohol spectrum disorder and its association with
Maryam H Alsameen1, Felicha T Candelaria-Cook1, Cassandra M Cerros2
1The Mind Research Network a Division of Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA.
Insights
Early brain connectivity differences in children with Fetal Alcohol Spectrum Disorder (FASD) are linked to attention and control deficits. These findings highlight the need for early interventions targeting neural network dysfunction in FASD.
Area of Science:
- Neuroscience
- Developmental Psychology
- Pediatrics
Background:
- Fetal Alcohol Spectrum Disorder (FASD) is linked to neurocognitive deficits, particularly in executive function, attention, and inhibitory control.
- Neural mechanisms of these deficits in young children (6-8 years) are not well understood.
- This study investigates functional connectivity (FC) alterations in brain networks crucial for inhibitory control and executive function in children with FASD.
Purpose of the Study:
- To investigate functional connectivity (FC) alterations in the Default Mode Network (DMN) and Frontal Parietal Network (FPN) in young children with FASD compared to typically developing controls (TDC).
- To explore the relationship between FC abnormalities and behavioral performance on tasks of attention and inhibitory control.
Main Methods:
- Seed-based connectivity (SBC) analysis was performed on 27 children with FASD and 30 TDC.
- Focus was on the medial prefrontal cortex (MPFC) within the DMN and FPN.
- FC differences were examined during resting-state conditions and correlated with Conners Continuous Performance Test (CPT) results.
Main Results:
- Children with FASD showed reduced FC between MPFC and limbic regions (amygdala, hippocampus, brainstem), indicating emotion regulation and cognitive control impairments.
- Altered FPN connectivity was observed in regions vital for higher-order cognitive processing.
- FC patterns correlated significantly with CPT performance, showing increased errors and reaction time variability, indicative of attention and response inhibition deficits.
Conclusions:
- Early disruptions in DMN and FPN functional connectivity are evident in young children with FASD.
- These neural alterations are associated with behavioral deficits in attention and cognitive control.
- Findings emphasize the importance of early identification and intervention for improving cognitive outcomes in FASD by targeting neural network dysfunction.
Background:
Fetal alcohol spectrum disorder (FASD) is associated with widespread neurocognitive deficits, including impairments in executive function, attention, and inhibitory control. However, understanding of the neural mechanisms underlying these deficits in young children 6-8 years of age remains limited. This study investigated functional connectivity (FC) alterations in key brain networks related to inhibitory control and executive function in children with FASD compared to typically developing controls (TDC).
Methods:
Seed-based connectivity (SBC) analysis was conducted in 27 children with FASD and 30 TDC, focusing on the medial prefrontal cortex (MPFC) within the Default Mode Network (DMN) and Frontal Parietal Network (FPN). FC differences were assessed across resting-state conditions (eyes closed vs. eyes open) and correlated with Conners Continuous Performance Test (CPT).
Results:
Children with FASD exhibited significantly reduced FC between MPFC and limbic regions, including the amygdala, hippocampus, and brainstem, suggesting impairments in emotion regulation and cognitive control. The FPN showed altered connectivity with the middle temporal gyrus and inferior lateral occipital cortex, regions crucial for higher order cognitive processing. Significant interactions between groups and resting-state condition were observed, with altered connectivity patterns in the MPFC and FPN suggesting sensory-motor and cognitive control disruptions. FC patterns in these networks were significantly correlated with CPT performance, including increased errors of omission and reaction time variability, indicating deficits in sustained attention and response inhibition.
Conclusion:
Our findings reveal early disruptions in FC within the DMN and FPN in young children with FASD, highlighting altered interactions between key brain regions implicated in inhibitory control and executive function. These neural alterations were associated with behavioral deficits in attention and cognitive control, suggesting that FC abnormalities may underlie core cognitive impairments in FASD. Findings underscore the importance of early identification and intervention strategies targeting neural network dysfunctions to improve cognitive outcomes in children with FASD.
