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Very Early Recurrence Following Liver Resection for Intrahepatic Cholangiocarcinoma: Is It Predictable by Clinical
Francesco Ardito1,2, Francesco Razionale1, Andrea Campisi1
1Hepatobiliary Surgery Unit, Foundation Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
ANZ Journal of Surgery
|August 28, 2025
Summary
Preoperative clinical factors cannot reliably predict very early recurrence in intrahepatic cholangiocarcinoma (ICC) patients after liver resection. Further research integrating molecular data is needed for personalized treatment strategies.
Area of Science:
- Hepatobiliary Surgery
- Surgical Oncology
- Gastroenterology
Background:
- Intrahepatic cholangiocarcinoma (ICC) recurrence after liver resection impacts prognosis.
- Very early recurrence (within 6 months) is common and associated with poor outcomes.
- Accurate prediction of recurrence is crucial for surgical patient selection.
Purpose of the Study:
- To evaluate if preoperative clinical factors alone can predict very early recurrence after curative ICC liver resection.
Main Methods:
- Retrospective analysis of 83 patients undergoing liver resection for ICC (2010-2020).
Main Results:
- 5-year overall survival was 51.4%.
- 65.1% experienced recurrence, with 20.5% having very early recurrence.
- Preoperative factors failed to identify high-risk patients; 21% of low-risk patients had very early recurrence.
Conclusions:
- Preoperative clinical factors are insufficient for accurate risk stratification of ICC recurrence.
- Integrating clinicopathological and molecular data is essential for personalized ICC treatment.
