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Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification
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Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification

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EP300/CREBBP induces osteogenic differentiation of valve interstitial cells by promoting the SPP1 expression in

Cheng Yu1, Ming Dong1, Danna Wu2

  • 1Department of Cardiovascular Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Number Nineteen, Xiuhua Road, Xiuyin District, Haikou, 570311 Hainan People's Republic of China.

Cytotechnology
|August 28, 2025
PubMed

Keywords:
Calcific aortic valve diseaseEP300/CREBBPOsteogenic differentiationSPP1Valve interstitial cells

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