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Updated: Sep 9, 2025

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
Awareness Campaigns to Prevent Diabetic Ketoacidosis at Diabetes Onset Are Successful When Constantly Maintained:
Martin Holder1, Jacqueline Weiler2, Reinhard W Holl3
1Pediatric Endocrinology and Diabetology, Klinikum Stuttgart-Olgahospital, Stuttgart, Germany.
Abstract:
Objective: To expand the effective local Stuttgart childhood diabetic ketoacidosis (DKA) prevention campaign to the federal state of Baden-Württemberg (BW) in Germany. Research Design and Methods: All public health departments (PHDs) in BW were invited to participate. The DKA-incidence at diabetes onset was compared between participating and nonparticipating districts, prior (2015-2020) and during the campaign (2021-2023). Results: A total of 3038 children and adolescents were newly diagnosed with type 1 diabetes in BW during the observation period. DKA was present in 990 children (32.6%), severe DKA in 346 (11.4%). In total 14 of 38 PHD (37%) participated. DKA rates increased both in participating (29.9%-36.3%) and in nonparticipating districts (27.0%-41.0%; p < 0.0001 for time-trend). However, there was a significant interaction between time-interval and the groups of districts (p < 0.03) reflecting a significant treatment effect in the intervention group. Conclusions: The expansion of our local awareness campaign was possible and successful.
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