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Adjusting key performance indicators in ART laboratories according to controlled ovarian stimulation protocol
Wei Chen1,2, Shiyuan Cheng1,2, Yan Liu1,2
1Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in Physiology
|August 28, 2025
Summary
Controlled ovarian stimulation (COS) protocols significantly affect key performance indicators (KPIs) in IVF/ICSI cycles. Tailoring KPIs to specific COS protocols can enhance laboratory efficacy and guide personalized patient strategies.
Area of Science:
- Reproductive Medicine
- Embryology
- In Vitro Fertilization
Background:
- Key performance indicators (KPIs) are crucial for embryo laboratory quality management.
- The impact of controlled ovarian stimulation (COS) protocols on these KPIs remains underexplored.
- This study investigates how different COS protocols influence established KPIs.
Purpose of the Study:
- To assess the variation in embryo laboratory KPIs across four distinct controlled ovarian stimulation (COS) protocols.
- To determine the association between specific COS protocols and key performance indicators.
- To provide a basis for personalized treatment strategies in assisted reproductive technology.
Main Methods:
- Retrospective analysis of 51,728 IVF/ICSI cycles (2014-2022).
- Cycles categorized into four COS groups: follicular phase long-acting GnRH-a, luteal phase short-acting GnRH-a, GnRH-antagonist, and micro-stimulation.
- Comparison of KPIs including blastocyst development and implantation rates, validated across age groups, using multivariable regression analysis.
Main Results:
- Significant differences in blastocyst development rate (BLR), good blastocyst development rate (GBLR), and implantation rate were observed across COS protocols.
- The luteal phase short-acting GnRH-a protocol showed higher GBLR but lower implantation rates compared to the follicular phase long-acting GnRH-a protocol.
- COS protocols significantly influenced KPIs across all age groups, with notable variations observed in women under 35.
Conclusions:
- Controlled ovarian stimulation (COS) protocols exert a significant influence on key performance indicators in IVF laboratories.
- Evaluating KPIs in the context of specific treatment protocols is essential for accurate laboratory efficacy assessment.
- Findings support the development of personalized strategies based on COS protocol selection and laboratory performance metrics.
