Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

145
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
145
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

614
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
614

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FPHC Wellbeing Charter: The 'Whys' and 'Hows' of the Charter.

Scandinavian journal of trauma, resuscitation and emergency medicine·2025
Same author

Effect of repurposed simvastatin on disability progression in secondary progressive multiple sclerosis (MS-STAT2): a phase 3, randomised, double-blind, placebo-controlled trial.

Lancet (London, England)·2025
Same author

Higher mortality in Extracorporeal Membrane Oxygenation patients during the COVID-19 pandemic compared with H1N1 influenza: implications for future pandemics.

Respiratory medicine·2025
Same author

Brain health - time matters: multiple sclerosis, neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and related conditions. 2024 report.

Multiple sclerosis and related disorders·2025
Same author

A New Perspective on the Management of Giant Rectal Polyps Presenting With McKittrick-Wheelock Syndrome: A Case Report on Treatment With Transanal Excision and Delorme's Plication.

Cureus·2025
Same author

A phase 1b clinical trial to determine the safety, tolerability and immunogenicity of simian adenovirus and poxvirus vectored vaccines against a Mycobacterium avium complex subspecies in patients with active Crohn's disease.

EBioMedicine·2025

Related Experiment Video

Updated: Sep 9, 2025

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

5.8K

Improving Appendicitis Prediction in Children Using the Paediatric Appendicitis Score (PAS): A Three-Year

Mhd Anas Murad1, Mohamed Elgaml2, Mohamad Wahib Zhlawi3

  • 1General and Colorectal Surgery, Southend University Hospital, Mid and South Essex NHS Foundation Trust, Southend-on-Sea, GBR.

Cureus
|August 28, 2025
PubMed
Summary

Implementing the Paediatric Appendicitis Score (PAS) in routine care improved risk stratification for childhood appendicitis. While not statistically significant, the negative appendicectomy rate decreased, showing potential for better diagnostic accuracy.

Keywords:
acute appendicitisappendicitis scorediagnosisnegative appendicectomypaediatric

More Related Videos

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

488
An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

21.5K

Related Experiment Videos

Last Updated: Sep 9, 2025

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

5.8K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

488
An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

21.5K

Area of Science:

  • Pediatric Surgery
  • Emergency Medicine
  • Diagnostic Accuracy

Background:

  • Acute appendicitis is a common pediatric surgical emergency with diagnostic challenges.
  • The Paediatric Appendicitis Score (PAS) aids risk stratification but real-world application varies.
  • Standardizing diagnosis is crucial to reduce negative appendicectomy rates.

Purpose of the Study:

  • To evaluate the impact of implementing the Paediatric Appendicitis Score (PAS) into routine clinical practice.
  • To assess the effect of an educational intervention on the negative appendicectomy rate and diagnostic accuracy.
  • To analyze the diagnostic performance of PAS in a district-general hospital setting.

Main Methods:

  • A two-cycle retrospective audit of 190 pediatric patients undergoing appendicectomy.
  • Introduction of an educational intervention and quick-reference guide based on the GIRFT abdominal pain pathway between cycles.
  • Evaluation of PAS diagnostic performance using sensitivity, specificity, predictive values, and AUC-ROC.

Main Results:

  • The negative appendicectomy rate decreased from 29.5% to 17.6% post-intervention (not statistically significant).
  • PAS ≥7 showed 87% specificity and 40% sensitivity; PAS ≥4 showed 96% sensitivity and 31% specificity.
  • Mean PAS was significantly higher in confirmed appendicitis cases (6.18 vs 4.69; p < 0.001), with an AUC-ROC of 0.73.

Conclusions:

  • Routine PAS implementation improved risk stratification and trended towards reduced negative appendicectomies.
  • High PAS scores (≥7) are specific, low scores (≤3) effectively rule out disease, and intermediate scores benefit from adjuncts.
  • Further multicenter studies incorporating imaging are recommended to enhance diagnostic accuracy and reduce negative appendicectomies.