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Related Experiment Video

Updated: Sep 9, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Prenatal Substance Exposure.

Rina D Eiden1,2, Kristin J Perry3, Miglena Y Ivanova1,3

  • 1Department of Psychology, The Pennsylvania State University, University Park, Pennsylvania, USA.

Annual Review of Developmental Psychology
|August 28, 2025
PubMed
Summary
This summary is machine-generated.

Prenatal substance exposure impacts neurodevelopment and behavior across the lifespan. Current research needs improved developmental frameworks and methods to understand co-exposure effects in children.

Keywords:
developmental outcomesearly adversitypregnancy substance useprenatal adversityprenatal substance exposure

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Public Health

Background:

  • Prenatal substance exposure is a significant concern with lifelong implications for neurobiological and behavioral development.
  • Existing research often lacks comprehensive developmental frameworks and fails to fully capture the lived experiences of affected children and families.

Purpose of the Study:

  • To conduct an evaluative review of the field of prenatal substance exposure.
  • To identify and discuss current conceptual and methodological limitations.
  • To propose future research directions for a more nuanced understanding.

Main Methods:

  • Systematic literature review and critical evaluation of existing studies.
  • Analysis of neurobiological and behavioral outcomes from infancy to young adulthood.
  • Assessment of methodologies used to study single and polysubstance exposures.

Main Results:

  • While common effects like altered fetal growth exist across substances, unique impacts are also observed.
  • Polysubstance exposure is prevalent, yet current models inadequately address coexposure effects.
  • Developmental frameworks incorporating family and child experiences are underutilized.

Conclusions:

  • The field requires enhanced developmental perspectives and methodologies to accurately assess prenatal substance exposure impacts.
  • Future research should prioritize understanding polysubstance exposure and employ more robust developmental models.
  • Addressing these limitations is crucial for improving interventions and outcomes for exposed children.