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Updated: Sep 9, 2025
Intraductal Delivery to the Rabbit Mammary Gland
Published on: March 9, 2017
Case Report: Breast ductal carcinoma in situ with microinvasion: a case tracked over 13 years
Sibei Ruan1, Jian Zhou1, Rui Tang1,2
1Department of Pathology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Background:
Numerous studies have reported considerable heterogeneity in breast ductal carcinoma in situ with microinvasion (DCIS-MI) regarding clinical presentation, progression potential, and treatment strategies.
Case Presentation:
In this work, we report a case of rapidly progressing multiple metastases in a patient with DCIS-MI following conventional treatment. Subsequent fluorescence in situ hybridization (FISH) testing revealed HER2 gene overexpression. After receiving 10 cycles of trastuzumab-targeted therapy, the patient achieved a favorable prognosis and remains stable to date.
Conclusion:
This case suggests that even patients with microinvasive lesions who are HER2-positive may exhibit unexpected stability under targeted therapy, warranting close surveillance in such cases.
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