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RETRACTION: Role of Matrix Metalloproteinase-9 Gene Polymorphisms in Glaucoma: A Hospital-Based Study in Chinese
Insights
This study on Matrix Metalloproteinase-9 gene polymorphisms and glaucoma in Chinese patients has been retracted due to significant statistical flaws and unavailable original data. The findings are unreliable.
Area of Science:
- Ophthalmology
- Genetics
- Medical Laboratory Analysis
Background:
- Glaucoma is a leading cause of irreversible blindness worldwide.
- Matrix Metalloproteinase-9 (MMP-9) gene polymorphisms have been investigated for their potential role in glaucoma pathogenesis.
- Understanding genetic predispositions is crucial for glaucoma research.
Purpose of the Study:
- To investigate the association between Matrix Metalloproteinase-9 gene polymorphisms and glaucoma in a Chinese patient cohort.
- To evaluate the potential role of MMP-9 genetic variations in the development or progression of glaucoma.
Main Methods:
- A hospital-based study design was employed.
- Genotyping of specific Matrix Metalloproteinase-9 gene polymorphisms was performed.
- Statistical analyses were intended to assess the correlation between genotypes and glaucoma status.
Main Results:
- The study reported findings on the association between MMP-9 gene polymorphisms and glaucoma.
- Specific genetic variations were analyzed in relation to the disease.
- However, the study has been retracted due to major flaws.
Conclusions:
- The original conclusions regarding the role of Matrix Metalloproteinase-9 gene polymorphisms in glaucoma are considered unreliable.
- The retraction was due to scientific inconsistencies and major flaws in statistical evaluation.
- Original data and ethical approval documentation were unavailable, preventing verification.
Retraction:
Zhao F. Fan Z. Huang X. Role of Matrix Metalloproteinase-9 Gene Polymorphisms in Glaucoma: A Hospital-Based Study in Chinese Patients Journal of Clinical Laboratory Analysis 34 no. 3 (2020): e23105, https://doi.org/10.1002/jcla.23105 The above article, published online on 12 November 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Rong Fu; and Wiley Periodicals LLC. The retraction has been agreed due to scientific inconsistencies and major flaws in the statistical evaluation. The journal received a request to retract this manuscript initially. During investigation, the authors stated that original data is no longer available and did not provide documentation for the ethical approval process of this study. Nanchong Central Hospital could not be reached for comment. Subsequently, the authors stopped responding. The conclusions of this manuscript are considered unreliable.
