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Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
Published on: November 17, 2017
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Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque
Yunqi Zhang1, Feifei Li2, Libo Liu1
1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, P. R. China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|August 28, 2025
Summary
Nanoparticle drug delivery systems (NDDSs) offer advanced atherosclerosis treatment by targeting lesions and responding to plaque microenvironments. These systems enhance efficacy and reduce side effects compared to traditional methods.
Area of Science:
- Cardiovascular Medicine
- Biomedical Engineering
- Nanotechnology
Background:
- Atherosclerosis is a major cause of cardiovascular disease with complex pathogenesis.
- Current treatments face limitations due to the multifaceted nature of the disease.
Purpose of the Study:
- To review pathophysiological mechanisms of atherosclerosis.
- To examine advances in nanoparticle drug delivery systems (NDDSs) for atherosclerosis treatment.
Main Methods:
- Systematic review of pathophysiological mechanisms.
- Analysis of recent developments in NDDSs for targeted atherosclerosis therapy.
Main Results:
- NDDSs can modulate cellular activities involved in atherosclerotic progression.
- Targeted delivery and stimulus-responsive release enhance therapeutic efficacy.
- NDDSs minimize systemic and off-target adverse effects.
Conclusions:
- NDDSs overcome limitations of traditional pharmacological treatments for atherosclerosis.
- Personalized interventions using NDDSs can attenuate disease progression, stabilize plaques, and promote regression.
- NDDSs hold transformative potential for redefining atherosclerosis treatment paradigms and improving patient outcomes.
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