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Updated: May 10, 2026

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
Primary Intrahepatic Biliary Neuroendocrine Neoplasms: A Case Report and Literature Review
Zhengfu Chen1, Lifu Hu2, Zixian Guo1
1Jilin University, Changchun, China.
Introduction:
Intrahepatic biliary neuroendocrine neoplasms (NENs) are rare neoplasms originating from neuroendocrine cells in the intrahepatic bile ducts. Patients often present without hormone-related symptoms but are admitted due to jaundice or abdominal pain.
Presentation Of Case:
This case report describes a 57-year-old female patient who experienced intermittent upper abdominal pain for one month prior to admission. A computed tomography (CT) scan at a local hospital revealed an intrahepatic space-occupying lesion. Magnetic Resonance Cholangiopancreatography (MRCP) at our hospital identified a mass at the root of the left hepatic duct, accompanied by secondary dilation of the left intrahepatic bile ducts. Liver function tests and tumor markers were within normal ranges, and no jaundice or metastatic signs were observed. The patient underwent robot-assisted left hemihepatectomy and cholecystectomy, with a smooth postoperative recovery. Pathological examination confirmed a neuroendocrine tumor (NET G2), measuring 2.2×2×1.6 cm. Postoperative positron emission tomography / computedtomography (PET/CT) scans detected no tumors elsewhere, confirming the intrahepatic bile duct as the primary site.
Conclusion:
Biliary NENs are exceedingly rare and challenging to diagnose preoperatively. Surgical resection remains the most effective treatment for achieving cure or prolonging survival.
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