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Hypoglycemia-Related Hospitalization in Adults with Type 2 Diabetes Receiving Insulin in Japan: Real-World Analysis
Takeshi Miyatsuka1, Maiko Kino2, Elisabeth de Laguiche3
1Department of Diabetes, Endocrinology and Metabolism, Kitasato University School of Medicine, 1-15-1, Kitasato, Minami-ku, Sagamihara, Kanagawa, Japan. miyatsuka.takeshi@kitasato-u.ac.jp.
Basal-bolus insulin therapy in Japanese adults with type 2 diabetes (T2D) is linked to more hypoglycemia-related hospitalizations compared to basal or premix insulin. This study highlights the importance of considering insulin type when managing T2D risks.
Area of Science:
- Endocrinology
- Pharmacology
- Public Health
Background:
- Limited data exists on hypoglycemia incidence in Japanese insulin-treated diabetes patients.
- Type 2 diabetes (T2D) management in Japan involves significant insulin use.
- Real-world data on hypoglycemia-related hospitalizations post-insulin initiation is scarce.
Purpose of the Study:
- To assess the incidence of hypoglycemia-related hospitalization after insulin initiation in Japanese adults with T2D.
- To determine the time to the first hypoglycemia-related hospitalization across different insulin types.
- To compare hypoglycemia risk among basal, basal-bolus, and premix insulin users.
Main Methods:
- Retrospective cohort analysis of adults with T2D initiating insulin (basal, basal-bolus, premix) from 2016-2022.
- Utilized the Medical Data Vision (MDV) database for patient data.
- Employed inverse probability of treatment weighting to control for confounding factors.
Main Results:
- A total of 65,668 patients were analyzed, with similar distribution across basal, basal-bolus, and premix insulin groups.
- The overall incidence of hypoglycemia-related hospitalization was 0.35 per 100 person-years.
- The basal-bolus group showed a significantly higher incidence of hypoglycemia-related hospitalization (0.41%) compared to basal (0.13%) and premix (0.15%) groups (p<0.001).
Conclusions:
- Basal-bolus insulin therapy is associated with a higher incidence of hypoglycemia-related hospitalizations in Japanese adults with T2D.
- The basal-bolus group experienced a shorter time to the first hypoglycemia-related hospitalization.
- These findings suggest careful consideration of insulin regimen choice to mitigate hypoglycemia risk in T2D patients in Japan.
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