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Related Experiment Video

Updated: Sep 9, 2025

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

Published on: March 17, 2023

NIR II Imaging-Guided Self-Illuminating Fiber-Optic Theranostics.

Junqiu Long^1,2, Zhiyuan Xu^1,2,3, Zesen Li^1,2

¹Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou 510632, China.

|August 28, 2025

Summary

This study introduces a novel fiber-optic probe for image-guided cancer therapy. The self-illuminating probe enhances tumor targeting and treatment efficacy, achieving a 100% cure rate in preclinical models.

Keywords:

fiber-optic sensors navigation photothermal therapy ratiometry imaging self-illuminating theranostics

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Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

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Published on: March 8, 2013

Area of Science:

Biomedical Engineering
Nanotechnology
Oncology

Background:

Fiber-optic technology faces limitations in in vivo navigation and light penetration for phototheranostics.
Current medical imaging modalities struggle with the "last-mile" intervention for precise treatment delivery.

Purpose of the Study:

To develop a near-infrared II (NIR-II) imaging-guided, self-illuminating fiber-optic theranostic probe.
To overcome limitations in current image-guided cancer therapy and improve minimally invasive treatment.

Main Methods:

Integrated NIR-II self-illumination for navigation and luminescent ratiometry for tumor identification.
Utilized erbium ions for visible upconversion luminescence and recycled excitation light for dual-mode imaging.
Employed multimodal thermal dose monitoring during photothermal therapy.

Main Results:

Achieved a 100% cure rate in murine xenograft models.
Reduced the number of fiber probes required by 33%.
Demonstrated deep tissue penetration (>10 mm) with a compact probe (<200 μm diameter).

Conclusions:

The developed platform offers a robust framework for minimally invasive cancer theranostics.
The self-illuminating probe enables precise, image-guided precision oncology.
This technology advances clinically translatable solutions for deep-seated tumor treatment.