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Central Line-Associated Bloodstream Infections in Pediatrics: A Review
Aarti C Bavare1,2, Catherine E Foster3,4, Amanda L Wollam2
1Division of Critical Care, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Insights
Central line-associated bloodstream infections (CLABSIs) are a significant concern in pediatric patients with central venous catheters. Evidence-based guidelines have successfully reduced CLABSI rates over the past two decades.
Area of Science:
- Pediatric Infectious Diseases
- Healthcare Epidemiology
- Infection Prevention
Background:
- Central line-associated bloodstream infections (CLABSIs) represent a major healthcare-associated infection in pediatric patients requiring central venous catheters.
- These infections pose significant risks to both hospitalized and non-hospitalized children.
Purpose of the Study:
- To provide a comprehensive review of CLABSIs in pediatric populations.
- To detail the definition, pathogenesis, risk factors, prevention strategies, and treatment principles for pediatric CLABSIs.
Main Methods:
- Review of existing literature and evidence-based guidelines.
- Synthesis of information from professional societies like the CDC and NHSN.
- Analysis of prevention and management strategies over the last two decades.
Main Results:
- Significant reductions in CLABSI rates have been achieved through guideline implementation.
- Evidence-based practices have demonstrably improved patient outcomes.
- The review consolidates current knowledge on CLABSI prevention and treatment.
Conclusions:
- CLABSI prevention in pediatric patients has advanced significantly due to standardized guidelines.
- Continued adherence to evidence-based practices is crucial for minimizing CLABSI incidence.
- This review serves as a resource for understanding and managing CLABSIs in children.
Abstract:
Central line-associated bloodstream infections (CLABSIs) are a common and significant health care-associated infection in hospitalized and nonhospitalized pediatric patients with central venous catheters. Interventions to prevent such infections have evolved over the last 2 decades, resulting in significant reductions in CLABSI rates through the development and implementation of evidence-based guidelines on prevention and management recommended by the Centers for Disease Control and Prevention and the National Healthcare Safety Network and pediatric infectious diseases and health care epidemiology professional societies. This review provides a detailed synopsis of CLABSIs in children, including the definition, pathogenesis, risk factors, prevention, and treatment principles.
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