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Updated: Sep 9, 2025
The Influence of Liver Resection on Intrahepatic Tumor Growth
Published on: April 9, 2016
Research Communication: Serum Metabolomic Signatures Predict Tumour Recurrence After Resection or Ablation in
Ashwini Arvind1, Hiroaki Kanzaki1, Fouzia Ahmed1
1Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
Abstract:
Patients with hepatocellular carcinoma (HCC) often experience recurrence after curative therapies, underscoring a need for risk stratification models. We validated 6 and 13-metabolite signatures in patients who achieved complete response following surgical resection or local ablation. Of 78 patients, 32 (41.0%) died and 40 (51.3%) experienced recurrence, of whom 35 (87.5%) had early recurrence. In multivariable analysis, the 6-metabolite signature was associated with early recurrence (aHR 2.8, 95% CI 1.1-7.5), and the 13-metabolite signature was associated with overall recurrence (aHR 2.5, 95% CI 1.1-6.0). These data support the potential role of serum metabolites in post-treatment risk stratification for HCC recurrence.
