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Clinical Characteristics and Outcomes of Adults with Budd-Chiari Syndrome: A Single-Center Experience in Colombia

Ximena Morales-Cruz1, Carolina Salinas2, Geovanny Hernández-Cely2

  • 1School of Medicine and Health Sciences, Hepatology Program, Universidad del Rosario, Bogota, Colombia, ximena.morales@urosario.edu.co.

Digestive Diseases (Basel, Switzerland)
|August 28, 2025
PubMed

Insights

Budd-Chiari syndrome in Colombia is linked to acquired thrombophilias, primarily antiphospholipid syndrome. This study highlights clinical features and mortality rates consistent with global findings for this rare liver disease.

Area of Science:

  • Hepatology
  • Vascular Medicine
  • Internal Medicine

Background:

  • Budd-Chiari syndrome involves hepatic venous outflow obstruction.
  • Limited data exists on Budd-Chiari syndrome in Colombia.
  • This study characterizes patients in a Colombian referral center.

Purpose of the Study:

  • To describe clinical characteristics of Budd-Chiari syndrome patients in Colombia.
  • To outline management strategies and survival rates.
  • To provide insights into this understudied population.

Main Methods:

  • Retrospective longitudinal study of 31 adult patients (2010-2022).
  • Data collected on demographics, risk factors, clinical presentation, and management.
  • Survival analysis was performed.

Main Results:

  • Acquired thrombophilias (58.1%) were the primary risk factor, mainly antiphospholipid syndrome.
  • Ascites (87.1%) was the most common presentation.
  • Mortality rate was 35.5%, with a median survival of 337.1 days.

Conclusions:

  • Budd-Chiari syndrome in Colombia is associated with acquired thrombophilias.
  • Clinical features and mortality align with international reports.
  • Further characterization of this disease in the region is warranted.
Abstract

Keywords:
Budd-Chiari syndromeCirrhosisLiver transplantTransjugular intrahepatic portosystemic shuntVein thrombosis

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