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Published on: October 13, 2016
Neuroanatomical Correlate of Memory Impairment in Parkinson's Disease Assessed by Composite Recall and Recognition
Yoko Sugimura1,2, Toru Baba3, Iori Kawasaki4
1Department of Cognitive and Motor Aging, Tohoku University Graduate School of Medicine, Sendai, Japan, sugimura.yoko.q7@dc.tohoku.ac.jp.
Abstract:
Introduction: Memory impairment in Parkinson's disease (PD) is characterized mainly by impaired recall with preserved recognition. Despite its clinical importance, there are only a limited number of simple bedside memory tests that can assess both recall and recognition memory together, and that can also be used to detect the neuroanatomical changes in PD. To address this issue, we examined whether a simple memory test that can evaluate both recall and recognition memory can detect cortical abnormalities related to memory impairment in PD.
Methods:
We designed a composite recall and recognition memory score using the Mini-Mental Statement Examination to reflect recall and recognition memory. We assessed memory impairment in 210 patients with PD using this test and investigated the neuroanatomical correlations with the test results.
Results:
This simple memory test showed that recognition memory was generally preserved in PD, and furthermore, the test results were significantly correlated with atrophy of the limbic and frontal cortices.
Conclusions:
Adding recognition evaluation to a simple memory test can detect abnormalities in memory-related brain regions in PD.
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