Different Response Criteria and Response Rates for Biologic Therapy in Patients With Chronic Rhinosinusitis With...

Area of Science:

• Otolaryngology
• Immunology
• Pharmacology

Background:

• Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex inflammatory condition.
• Biologic therapies offer new treatment avenues for CRSwNP.
• Standardized response criteria are crucial for evaluating biologic treatment efficacy.

Purpose of the Study:

• To systematically review and summarize current response criteria for biologic therapies in CRSwNP.
• To evaluate the response rates of CRSwNP patients undergoing biologic treatment based on existing criteria.

Main Methods:

• Systematic literature search of PubMed, Embase, Web of Science, and Cochrane Library up to July 2024.
• Inclusion of clinical studies on biologic treatment response in CRSwNP.
• Meta-analysis of data from 25 studies involving 3735 patients.

Main Results:

• Twenty-nine studies were included, utilizing various comprehensive and single response criteria.
• Comprehensive criteria assessed nasal polyp size, corticosteroid need, quality of life, smell, and comorbidities.
• Pooled moderate-to-excellent response rates ranged from 39.3% to 87.7% with comprehensive criteria and 62.9% to 82.8% with single measures.

Conclusions:

• Significant heterogeneity exists in response rates due to the lack of standardized criteria for CRSwNP patients on biologic treatment.
• Development of consistent response criteria is essential for accurately defining biologic treatment efficacy in CRSwNP.