Related Experiment Video
Updated: Sep 9, 2025

Murine Nasal Lavage Fluid Collection without Blood Contamination
Published on: July 11, 2025
Nationwide descriptive epidemiological study of epistaxis treatment using the national database of Japan
Seiichiro Makihara1, Kensuke Uraguchi2, Shohei Fujimoto1
1Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Objective:
The aim of this study was to analyze nationwide patterns of epistaxis treatment in Japan, including temporal trends, demographic distributions, and regional variations. This was a nationwide descriptive observational study using a national administrative database.
Methods:
We analyzed open data of the National Database of Health Insurance Claims from fiscal years 2019-2022 to examine two treatment procedures for epistaxis: hemostasis with gauze packing and cauterization. Treatment patterns were evaluated by month, age, sex, and prefecture of residence. The standardized claim ratio was calculated using indirect standardization for regional comparisons RESULTS: During the study period, 870,819 gauze-packing procedures and 523,591 cauterization procedures were recorded. Both procedures exhibited consistent seasonal patterns, peaking in winter (December to February). Age distribution followed a bimodal pattern, with higher incidence in children and older adult individuals, and a male predominance across all age groups. Pediatric patients were more likely to receive gauze packing. Geographic analysis showed a preference for gauze packing in Western Japan, whereas cauterization was more frequently performed in Northern Japan, suggesting a potential association with higher latitudes.
Conclusion:
This is the first nationwide study to identify distinct seasonal, demographic, and regional variations in epistaxis treatment in Japan. These findings suggest that factors beyond climate may influence treatment selection.
Related Concept Videos
Epistaxis
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Statistical Methods for Analyzing Epidemiological Data

