Injectable amino-modified poly-L-lactic acid microspheres/hyaluronic acid-based hydrogel composites for soft tissue
Chen Shen1, Xingyu Zhou1, Junhui Jiang1
1Key Laboratory of High Performance Plastics, Ministry of Education, College of Chemistry, Jilin University, Changchun 130012, PR China.
Biomaterials Advances
|August 28, 2025
Summary
This study introduces a novel injectable soft tissue filler using modified hyaluronic acid and poly-L-lactic acid microspheres. The composite filler enhances skin aging treatment by promoting collagen production and offering long-term efficacy.
Area of Science:
- Biomaterials Science
- Dermatology
- Regenerative Medicine
Background:
- Soft tissue fillers are crucial for treating skin aging and volume loss.
- Developing safe and effective fillers remains a significant challenge in aesthetic medicine.
Purpose of the Study:
- To develop a synergistic composite injectable soft tissue filler with enhanced safety and efficacy.
- To evaluate the performance of a novel composite hydrogel in a skin aging model.
Main Methods:
- Formulation of a composite hydrogel using aldehyde-modified hyaluronic acid (OHA), hydrazide-modified hyaluronic acid (NHA), amino-modified poly-L-lactic acid microspheres (NPLLA), and copper peptide.
- In situ hydrogel formation via Schiff base reaction.
- Evaluation of mechanical properties, agglomeration, and in vivo efficacy in a nude mice skin aging model.
Main Results:
- The composite hydrogel demonstrated excellent mechanical properties and an immediate filling effect.
- NPLLA microspheres reduced agglomeration, minimizing adverse reactions and improving mechanical strength.
- The filler promoted collagen deposition via the TGF-β/Smad pathway, showing long-term efficacy in vivo.
Conclusions:
- The NPLLA microspheres/hyaluronic acid-based composite hydrogel is a promising candidate for injectable soft tissue fillers.
- This novel filler formulation offers a potential solution for safe and effective treatment of skin aging and volume restoration.
