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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Giardiasis and Eosinophilia in Outpatients with Gastrointestinal Symptoms: A Case Series
Laura Niño-Puerto1, Belén Vicente1, Josué Pendones Ulerio2
1Grupo Enfermedades Infecciosas y Tropicales (e-INTRO), Instituto de Investigación Biomédica de Salamanca (IBSAL), Centro de Investigación de Enfermedades Tropicales de la Universidad de Salamanca (CIETUS), Facultad de Farmacia, Universidad de Salamanca, Salamanca, Spain.
Abstract:
Eosinophilia is frequently observed among individuals with soil-transmitted helminth infections, although its connection with Giardia intestinalis is somewhat ambiguous. In this study, 66 outpatients diagnosed with giardiasis were analyzed at Complejo Asistencial Universitario de Salamanca in Spain between 2021 and 2024. Outpatients presented with diarrhea and abdominal pain and were diagnosed via stool microscopy. Eosinophilia, defined as >450 eosinophils/µL, was observed in 45% (30/66) of cases, with a mean eosinophil count of 663 ± 522 cells/µL. After treatment with metronidazole or tinidazole, eosinophil counts significantly decreased to 219 ± 178 cells/µL. These findings suggest an association between Giardia intestinalis infection and eosinophilia, highlighting the importance of including Giardia intestinalis in the differential diagnosis of unexplained eosinophilia in outpatients experiencing gastrointestinal symptoms.
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