Accelerated biological aging among chemical plant workers

Area of Science:

• Occupational health
• Toxicology
• Gerontology

Background:

• The link between occupational chemical exposures and biological aging is not well-established.
• This study investigates associations between coke oven emissions (COEs), benzene, methanol, and coal dust with accelerated biological aging in workers.

Purpose of the Study:

• To examine the relationship between specific occupational chemical exposures and biological aging metrics.
• To identify which chemical exposures are most strongly associated with accelerated aging.

Main Methods:

• 2621 workers from a Chinese chemical plant were assessed for occupational exposure.
• Biological age accelerations (KDM-BAacc, immuneBAacc, cardio-metabolismBAacc, liver-kidneyBAacc) were calculated using the Klemera and Doubal method (KDM) based on 10 biomedical indicators.
• General linear regression models analyzed the associations between exposure groups and biological age metrics.

Main Results:

• Exposure to COEs, benzene, and coal dust significantly increased KDM-BAacc and cardio-metabolismBAacc compared to controls.
• Associations were significant in younger workers (18-44 years) and more pronounced in females.
• Significant interactions between gender and COEs exposure were observed.

Conclusions:

• Occupational exposure to COEs, benzene, and coal dust can accelerate biological aging, impacting cardiovascular and metabolic systems.
• Findings highlight the need for enhanced occupational safety and health monitoring in industries with high chemical exposure risks.
• Preventing premature aging and improving worker health are key public health objectives.