Related Experiment Video
Updated: Sep 9, 2025

Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
Histone acetylation: A key regulator of inflammatory responses
Siqi Gao1, Hua Xiao1, Haodang Luo2
1Institute of Pathogenic Biology, School of Basic Medical Science, Hengyang Medical College, University of South China; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hengyang City, Hunan Province 421001, PR China.
None:
Histone acetylation is a critical epigenetic modification that influences several biological processes by altering chromatin structure and regulating gene expression, including chromatin remodeling, DNA replication, transcriptional regulation, signal transduction, autophagy, differentiation, and inflammatory responses. In eukaryotic cells, it ranks as one of the most common posttranslational modifications of histones and the earliest confirmed important positive transcriptional regulators. This review discusses the regulation of histone acetylation on the inflammatory response and comprehensively introduces the influence of histone acetylation on inflammation-related signaling pathways, pathogen infection, and inflammatory diseases. It is expected that this will provide new ideas and insights for the further development and application of histone acetylation inhibitors as therapeutic targets for inflammatory diseases.
Related Concept Videos
Histone Modification
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Spreading of Chromatin Modifications
Writers
The writer...
Chromatin Modification in iPS Cells
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...

