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Impact of 10-day bed rest on neuromuscular junction instability in healthy elderly males

Mohamed Osman Abdalla1, Mackenzie Ziegler1, Drake Christie1

  • 1Centre for Bone and Muscle Health, Department of Health Sciences, Faculty of Applied Health Sciences, Brock University, St Catharines, Ontario, Canada.

The Journal of Physiology
|August 28, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
ageingelectromyogrammuscle atrophyneuromuscular junction

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Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
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