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Endometriosis Presenting as a Malignant Appearing Cecal Mass
Akanksha Togra1, M Ammar Kalas2, Keith Garrison2
1Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, USA.
Journal of Investigative Medicine High Impact Case Reports
|August 28, 2025
Summary
Gastrointestinal endometriosis, though rare, can mimic colon cancer, presenting as a cecal or appendiceal mass. Early diagnosis and surgical intervention are key for effective management of this gynecological condition.
Area of Science:
- Gynecology
- Gastroenterology
- Surgical Pathology
Background:
- Endometriosis is a gynecological condition characterized by endometrial tissue outside the uterus.
- It commonly affects pelvic organs but can occur in extra-pelvic sites, including the gastrointestinal tract.
- Cecal and appendiceal endometriosis are rare but can present with symptoms mimicking malignancy, such as anemia.
Purpose of the Study:
- To present a case of a 50-year-old female with symptomatic anemia due to extensive endometriosis involving the cecum and appendix.
- To highlight the diagnostic challenges and the importance of considering endometriosis in the differential diagnosis of colonic masses.
- To emphasize the role of surgical intervention in suspected cases.
Main Methods:
- A case report of a 50-year-old female presenting with symptomatic anemia.
- Diagnostic workup included imaging (CT scan) and colonoscopy with biopsy.
- Surgical resection of the affected area followed by histopathological examination.
Main Results:
- Imaging revealed a cecal and appendiceal mass with lymphadenopathy, initially suspicious for malignancy.
- Colonoscopy showed a suspicious tumor, but biopsy results were inconclusive.
- Surgical resection confirmed extensive endometriosis involving the cecum and appendix, mimicking neoplasia.
- The patient's anemia resolved postoperatively.
Conclusions:
- Gastrointestinal endometriosis can present as a colonic mass, posing a diagnostic challenge and necessitating a broad differential diagnosis.
- Symptomatic anemia in the context of a suspected colonic mass should prompt consideration of endometriosis.
- Surgical intervention is crucial for diagnosis and treatment when malignancy is suspected.
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