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Published on: May 21, 2019
Visible-Light-Driven Photoredox-Catalyzed Radical Cyclization via a TEMPO-Intercepted Cascade: Regioselective and
Qi Jiang1, Keyuan Zhang1, Mingyou Hu1
1School of Chemistry, Engineering Research Center of Energy Storage Materials and Devices, Ministry of Education, Xi'an Key Laboratory of Sustainable Energy Material Chemistry, Xi'an Jiaotong University, Xi'an 710049, China.
Abstract:
A visible-light-driven regioselective intramolecular cyclization and oxidation cascade of γ-alkynyl β-sulfonylester is developed. This metal-free approach efficiently affords synthetically useful cyclopentene and cyclohexene skeletons under mild conditions, with TEMPO acting as a dual electron and oxygen atom donor. Mechanism investigations support a radical cyclization/TEMPO-trapping cascade.
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