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Survival Outcome for Peptide Receptor Radionuclide Therapy in Olfactory Neuroblastoma
Hidenori Suzuki1, Hiroya Taniguchi2, Yoshitaka Inaba3
1Department of Head and Neck Surgery, Aichi Cancer Center, Nagoya, Japan hi.suzuki@aichi-cc.jp.
Background/Aim:
Systemic therapy for olfactory neuroblastoma with unresectable multi-recurrence disease is unestablished. However, peptide receptor radionuclide therapy (PRRT) with 177Lu-pentetreotide is considered to be an effective systemic treatment for unresectable multi-recurrence olfactory neuroblastoma expressing somatostatin receptors. This study investigated the association between survival outcome and treatment modality in olfactory neuroblastoma, with a focus on peptide receptor radionuclide therapy.
Patients And Methods:
Twenty-three patients with olfactory neuroblastoma who underwent initial definitive treatment from 1998 to 2023 were enrolled in this retrospective study.
Results:
Patients who underwent surgery were significantly associated with longer local recurrence-free survival from the initial definitive treatment compared to those who underwent radiotherapy. Among 18 patients with residual disease or first recurrence, those with distant metastasis related significantly with shorter overall survival from the diagnosis day of residual disease/first recurrence. Among 11 patients with unresectable multi-recurrent olfactory neuroblastoma, the 3 patients who received PRRT had significantly longer overall survival from the time of diagnosis compared to the 8 patients who did not receive PRRT.
Conclusion:
PRRT was associated with improved survival in patients with unresectable multi-recurrent olfactory neuroblastoma.
Insights
Peptide receptor radionuclide therapy (PRRT) improved survival for patients with unresectable, recurrent olfactory neuroblastoma. This systemic treatment offers a promising option for advanced cases.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiotherapy
Background:
- Olfactory neuroblastoma (ONB) with unresectable, multi-recurrence disease lacks established systemic therapy.
- Peptide receptor radionuclide therapy (PRRT) using 177Lu-pentetreotide is a potential treatment for somatostatin receptor-expressing ONB.
Purpose of the Study:
- To investigate the association between treatment modality and survival outcomes in olfactory neuroblastoma.
- To evaluate the efficacy of PRRT in patients with unresectable, multi-recurrent ONB.
Main Methods:
- Retrospective study of 23 patients with ONB treated between 1998 and 2023.
- Comparison of survival outcomes based on treatment modality (surgery, radiotherapy, PRRT).
Main Results:
- Surgery was associated with longer local recurrence-free survival than radiotherapy.
- Distant metastasis significantly correlated with shorter overall survival.
- PRRT significantly improved overall survival in patients with unresectable, multi-recurrent ONB compared to those not receiving PRRT.
Conclusions:
- PRRT is associated with improved survival in patients with unresectable, multi-recurrent olfactory neuroblastoma.
- PRRT represents a viable systemic treatment option for advanced ONB.
