Related Experiment Video
Updated: Sep 9, 2025

08:15
Polymeric Microneedle Array Fabrication by Photolithography
Published on: November 17, 2015
12.3K
Recent Advances in Microneedle Technology for Skin Antiaging
Bin Liu1, Liping Zhao2, Ziyu Wang1
1Cancer Research Centre, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, 101149, China.
ACS Applied Bio Materials
|August 28, 2025
Summary
Microneedle (MN) technology offers a promising solution for skin aging by creating microchannels that stimulate natural regeneration. This review explores MNs
Area of Science:
- Dermatology and Aesthetic Medicine
- Biotechnology and Biomedical Engineering
Background:
- The aging population and demand for aesthetic enhancements drive innovation in antiaging treatments.
- Skin aging involves complex mechanisms including structural breakdown, barrier dysfunction, and metabolic changes.
Purpose of the Study:
- To review the principles, structural features, and mechanisms of microneedle (MN) technology in relation to skin aging.
- To explore current dermatological applications and evaluate the clinical efficacy of MNs for antiaging.
- To discuss future research directions and challenges for MN technology in aesthetic medicine.
Main Methods:
- Review of scientific literature on microneedle technology and skin aging.
- Analysis of clinical studies assessing the efficacy of MN treatments for skin aging.
- Discussion of the underlying mechanisms of MNs in stimulating skin repair and regeneration.
Main Results:
- Microneedle technology creates microchannels that promote skin healing, enhance drug delivery, and improve skin vitality and elasticity.
- MNs address key aging mechanisms by providing mechanical stimulation and restoring skin barrier function.
- Clinical evidence supports the efficacy of MN technology in achieving significant antiaging effects.
Conclusions:
- Microneedle technology presents a viable and innovative approach to combating skin aging.
- Further research is needed to standardize protocols, evaluate long-term effects, and address patient variability for wider clinical adoption.
- Overcoming current challenges will be crucial for the broader implementation of MN technology in dermatological treatments.
Related Concept Videos
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
Tissue Renewal without Stem Cells
1.8K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
1.8K
Renewal of Skin Epidermal Stem Cells
2.6K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.6K

