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Multimodality Diagnosis of Mesenteric Ischemia
05:07

Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

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Risk Factors for 30-day Mortality After Emergency Surgery for Non-occlusive Mesenteric Ischemia

Yume Minagawa1,2, Yasuhiro Ishiyama3,2, Manabu Amiki3

  • 1Department of Gastroenterological Surgery, Kawasaki Saiwai Hospital, Kawasaki, Japan; mngw710yume.va@gmail.com.

In Vivo (Athens, Greece)
|August 28, 2025
PubMed
Abstract

Insights

Non-occlusive mesenteric ischemia (NOMI) is a severe condition. Chronic kidney disease, hemodialysis, high lactate dehydrogenase (LDH), and low platelet count are key risk factors for 30-day mortality after emergency surgery for NOMI.

Area of Science:

  • Gastroenterology
  • Vascular Surgery
  • Critical Care Medicine

Background:

  • Non-occlusive mesenteric ischemia (NOMI) is a rare, highly fatal condition.
  • It involves intestinal ischemia or necrosis without mesenteric vessel obstruction.
  • NOMI poses significant challenges in emergency surgical settings.

Purpose of the Study:

  • To identify risk factors for 30-day mortality in patients undergoing emergency surgery for NOMI.
  • To analyze patient characteristics and outcomes associated with NOMI survival.
  • To determine predictors of early death following NOMI surgical intervention.

Main Methods:

  • Retrospective analysis of 42 consecutive patients with NOMI undergoing emergency surgery.
  • Patients were categorized into 30-day mortality (n=9) and survival (n=33) groups.
  • Comparison of patient demographics, medical history, surgical outcomes, and laboratory values between groups.

Main Results:

  • The overall 30-day mortality rate for NOMI was 21.4%.
  • Patients with 30-day mortality showed higher prevalence of chronic kidney disease (CKD) and hemodialysis.
  • Lower platelet counts and elevated preoperative lactate dehydrogenase (LDH) >1,127 U/l were significantly associated with mortality.

Conclusions:

  • Chronic kidney disease (CKD) and hemodialysis are significant risk factors for NOMI mortality.
  • Elevated lactate dehydrogenase (LDH) levels and low platelet counts independently predict early death in NOMI patients.
  • These findings aid in risk stratification and management of NOMI patients undergoing emergency surgery.
Keywords:
Non-occlusive mesenteric ischemiaearly mortality

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