Related Experiment Video
Updated: Sep 9, 2025

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
Published on: May 26, 2023
Neurally adjusted ventilatory assist in critical care patients with and without obesity: a prospective randomized
Matthieu Conseil1,2, Samir Jaber3,4, Fabrice Galia1
1Department of Anaesthesiology and Critical Care Medicine B (DAR B), Saint-Eloi Hospital, University Teaching Hospital of Montpellier, 80 avenue Augustin Fliche, Montpellier, 34295, France.
Background:
Neurally Adjusted Ventilatory Assist (NAVA) compared to Pressure Support Ventilation (PSV) improves patient-ventilator interactions in intensive care unit. No study has evaluated NAVA in patients with obesity. We aimed to assess the feasibility and safety of NAVA in patients with obesity, and to compare NAVA in patients with versus without obesity.
Methods:
In this randomized cross-over study, all respiratory cycles during 1 h of mechanical ventilation from 10 patients with obesity and 11 without obesity were analyzed. Patients underwent 30 min of NAVA and 30 min of PSV in a random order. Flow, airway pressure and diaphragm electrical activity were continuously recorded. Arterial blood gases were obtained at baseline and at the end of each 30-min period. Patient-ventilator interactions were assessed with trigger delay, inspiratory time in excess, rate and type of dyssynchrony cycles. Variability of the ventilatory parameters was evaluated by the coefficient of variation (SD/mean).
Results:
All patients concluded the study, with a total of 1790 ± 873 respiratory cycles analyzed per patient. In patients with obesity, NAVA versus PSV was associated with a significant reduction in trigger delay (0 [0-5] vs. 106 [34-125] ms, p < 0.05), inspiratory time in excess (96 [94-102] vs. 145 [137-202] ms, p < 0.01) and in ineffective efforts (0 [0-0.03] vs. 0.33 [0.23-0.37] events/min, p < 0.05). The global dyssynchrony index remained similar in both modes (2.2% [1.1-4.4] vs. 3.7% [2.4-5.6], p = 0.68). Compared to PSV, PaO2/FiO2 ratio significantly increased in NAVA, 238 mmHg [174-344] versus 207 mmHg [164-297], p < 0.05. The tidal volume was significantly lower during NAVA than during PSV, 6.7 mL/kg predicted body weight [5.9-7.1] versus 7.2 mL/kg [6.2-8.2], p < 0.05. Ventilatory variability was significantly higher with NAVA, 16% [11-21] versus 4% [2-4] in mean inspiratory airway pressure. These results were similar in patients without obesity and the obesity factor was never significant. No adverse event was observed in patients with and without obesity in both modes.
Conclusion:
In patients with obesity, NAVA ventilation is feasible and safe, improves patient-ventilator interactions and oxygenation, with an increase ventilatory variability compared to PSV. The effects of NAVA are comparable in patients with and without obesity.
Related Concept Videos
Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive Positive-Pressure Ventilation...
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation I: Indication and Settings
Ventilatory Modes
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...

