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Chemical Modifications in Nucleic Acid Therapeutics

Kim A Lennox1, Rebecca C Young2, Mark A Behlke3

  • 1Integrated DNA Technologies, Inc., Coralville, IA, USA. klennox@idtdna.com.

Methods in Molecular Biology (Clifton, N.J.)
|August 28, 2025
PubMed
Summary

Chemically modified nucleic acid-based therapies (NATs) are advancing rapidly, offering new treatments for rare diseases. Innovations in chemical modifications enhance drug efficacy and safety, paving the way for more nucleic acid medicines.

Keywords:
ASOAntisenseCRISPRCas12aCas9Chemical modificationGuide RNAOligonucleotidesRNAicrRNAmRNAsgRNAsiRNA

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