Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Mismatch Repair01:20

Mismatch Repair

5.2K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
5.2K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.4K
Abnormal Proliferation02:23

Abnormal Proliferation

4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Proteoglycans01:05

Proteoglycans

4.0K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An investigation of the abnormalities in the microbiome‑gut‑brain axis in betel quid chewers.

Scientific reports·2026
Same author

SMARCA4 loss reprograms p300 chromatin occupancy to subvert p53-mediated transcriptional repression in ovarian small cell carcinoma.

Nature communications·2026
Same author

RCAF-Net: Wildlife Target Detection in Complex Forest Scenarios.

Animals : an open access journal from MDPI·2026
Same author

Knocking down FAM110A suppresses colon adenocarcinoma progression by inhibiting the Nrf2/HO-1 axis to induce ferroptosis.

World journal of surgical oncology·2026
Same author

In vivo membrane engineering traps Gd-based MRI contrast agents for detecting microhepatocellular carcinoma.

Science advances·2026
Same author

Intrauterine platelet-rich plasma and subsequent endometrial pathology evaluation in a patient undergoing a frozen embryo transfer cycle: a case report.

Journal of assisted reproduction and genetics·2026

Related Experiment Video

Updated: Sep 9, 2025

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay
13:10

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay

Published on: June 9, 2017

10.1K

Damage-associated molecular patterns (DAMPs) in diseases: implications for therapy.

Heya Lin1, Wei Xiong1, Lili Fu1

  • 1School of Stomatology, Zunyi Medical University, Zunyi, Guizhou, China.

Molecular Biomedicine
|August 28, 2025
PubMed
Summary

Damage-associated molecular patterns (DAMPs) are danger signals from stressed cells that trigger immune responses. This review explores DAMPs, their roles in diseases like cancer, and therapeutic strategies targeting DAMPs and pattern recognition receptors (PRRs).

Keywords:
Damage-associated molecular patternsImmune responsePathwaysPattern recognition receptorsTherapeutic strategies

More Related Videos

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.1K
Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications
10:12

Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications

Published on: April 21, 2023

2.9K

Related Experiment Videos

Last Updated: Sep 9, 2025

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay
13:10

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay

Published on: June 9, 2017

10.1K
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.1K
Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications
10:12

Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications

Published on: April 21, 2023

2.9K

Area of Science:

  • Immunology
  • Molecular Biology
  • Pathophysiology

Background:

  • Damage-associated molecular patterns (DAMPs) are endogenous molecules released by stressed or dying cells.
  • DAMPs bind to pattern recognition receptors (PRRs), initiating immune and inflammatory responses.
  • These processes are critical in various pathophysiological conditions.

Purpose of the Study:

  • To classify DAMPs based on molecular characteristics and functions.
  • To analyze DAMPs' roles in diseases such as cancer, cardiovascular, and respiratory disorders.
  • To review current and potential therapeutic strategies targeting the DAMP/PRR signaling axis.

Main Methods:

  • Classification of DAMPs into protein-based, nucleic acid-based, and mitochondria-derived categories.
  • Systematic review of DAMP molecular transformation, release, and recognition mechanisms.
  • In-depth analysis of DAMP/PRR interactions and downstream signaling pathways (NF-κB, MAPK, inflammasomes, cGAS-STING).

Main Results:

  • DAMPs play significant pathological roles in cancer, cardiovascular diseases, and respiratory disorders.
  • Current therapeutic strategies include modulating cell death, antibody neutralization, small-molecule inhibitors, and gene silencing.
  • Challenges in clinical translation include DAMP heterogeneity and drug delivery.

Conclusions:

  • Targeting the DAMP/PRR axis offers potential therapeutic avenues for cancer, neurodegenerative, cardiovascular, and inflammatory diseases.
  • Future solutions may involve nanoparticle delivery, AI-driven treatments, and gene editing.
  • Further research is needed to overcome clinical translation challenges for DAMP/PRR-targeted therapies.