Related Experiment Video
Updated: Sep 9, 2025
08:17
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
11.1K
Emphysema progression risk in COPD using a localized foundational model of density evolution.
Ariel H Curiale1, Carrie Pistenmaa2, Rubén San José Estépar3
1Applied Chest Imaging Laboratory, Department of Radiology and Medicine, Brigham and Women's Hospital, Harvard Medical School, 399 Revolution Drive, Somerville, 02145, MA, USA. acuriale@bwh.harvard.edu.
NPJ Digital Medicine
|August 28, 2025
Summary
A new Local Emphysema Progression (LEP) score accurately predicts emphysema advancement in chronic obstructive pulmonary disease (COPD) patients. This tool aids in early risk identification for better disease management and prognosis.
Area of Science:
- Radiology
- Pulmonary Medicine
- Computational Biology
Background:
- Emphysema progression in COPD is highly variable, lacking reliable prognostic markers.
- Limited therapeutic options necessitate early detection and intervention strategies for rapid progressors.
- Identifying at-risk individuals is crucial for slowing disease advancement.
Purpose of the Study:
- To develop and validate a novel method for pinpointing localized radiographic indicators of emphysema progression.
- To introduce the Local Emphysema Progression (LEP) score as a subject-level risk assessment tool.
- To evaluate the LEP score's correlation with disease severity and association with clinical outcomes.
Main Methods:
- Utilized a localized foundational model of density evolution to identify radiographic embeddings of emphysema progression.
- Calculated the LEP score by aggregating localized lung tissue activations.
- Validated the model on COPDGene (n=3728) and ECLIPSE (n=1058) cohorts, analyzing baseline to 5-year and 5-year to 10-year intervals.
Main Results:
- The model achieved an AUC of 0.88 in identifying lung regions with emphysema progression.
- LEP risk score demonstrated good correlation with change in low attenuation areas (Δ%LAA-950) (r=0.50 COPDGene, r=0.40 ECLIPSE).
- LEP score associated with mortality and other COPD outcomes.
Conclusions:
- The LEP score is a promising, novel metric for assessing emphysema progression risk in COPD patients.
- This tool can aid in early detection and personalized management strategies.
- LEP score's association with clinical outcomes highlights its potential clinical utility.
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.9K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.9K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
3.1K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
3.1K
01:20COPD: Pathogenesis and Clinical Features
516
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
516
01:22Chronic Obstructive Pulmonary Disease
1.4K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.4K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.9K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.9K
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.6K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.6K