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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Pronounced Disparities in Amyloidosis Cardiovascular Mortality Among Elderly Adults in the United States from

Mustafa Shehzad1, Dawood Shehzad2, Logan Johnke2

  • 1Internal Medicine Residency Program, Hackensack University Medical Center.

South Dakota Medicine : the Journal of the South Dakota State Medical Association
|August 29, 2025
PubMed

Insights

Cardiovascular mortality from amyloidosis (a protein-folding disorder) significantly increased in US adults over 65 from 1999-2020. Disparities exist by sex, race, and region, necessitating targeted public health interventions.

Area of Science:

  • Cardiovascular Medicine
  • Gerontology
  • Public Health

Background:

  • Amyloidosis involves protein misfolding and amyloid fibril accumulation, causing organ dysfunction.
  • Cardiovascular complications are a major concern in amyloidosis patients.
  • Understanding mortality trends is crucial for public health strategies.

Purpose of the Study:

  • To investigate trends in cardiovascular mortality associated with amyloidosis in the U.S. older adult population (≥65 years) from 1999 to 2020.
  • To identify demographic, racial, and geographic disparities in these mortality trends.
  • To inform targeted interventions and improve patient outcomes.

Main Methods:

  • Utilized the CDC WONDER database for U.S. mortality data from 1999 to 2020.
  • Analyzed age-adjusted mortality rates (AAMR) for amyloidosis-related cardiovascular deaths.
  • Stratified data by age, sex, race, and geographic region.

Main Results:

  • Overall AAMR increased from 1.71 in 1999 to 4.23 in 2020, with accelerated growth post-2018 (+16.30% annually).
  • Males and non-Hispanic Black individuals exhibited higher AAMR compared to females and other racial groups, respectively.
  • The Northeast and West regions showed the highest mortality rates, while the South had lower rates despite a larger Black population.

Conclusions:

  • Significant increases and disparities in amyloidosis-related cardiovascular mortality highlight the need for public health attention.
  • Observed trends may reflect improved diagnosis and reporting rather than solely increased prevalence.
  • Urgent need for targeted interventions, enhanced diagnostics, and treatment strategies to address disparities and manage the growing burden of amyloidosis.

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