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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

659
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
659
Cancer Vaccines01:30

Cancer Vaccines

509
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

1.9K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Updated: Sep 9, 2025

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
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Boosting Dendritic Cell Function in Cancer.

Evangelos Giampazolias1

  • 1Cancer Immunosurveillance Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.

Cancer Medicine
|August 29, 2025
PubMed
Summary
This summary is machine-generated.

Dendritic cells (DCs) are crucial for T cell immunity against cancer. Understanding DC functions can improve T cell-based cancer immunotherapies, including immune checkpoint blockade.

Keywords:
T cell primingactivationantigen presentationcancer immunitydendritic cellsimmunotherapy

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Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are critical immune cells that initiate T cell responses.
  • DCs play a significant role in anti-cancer immunity and the effectiveness of immunotherapies.
  • DCs detect pathogens and tissue damage via various receptors, influencing anti-tumour immunity.

Purpose of the Study:

  • To review the fundamental principles of dendritic cell biology.
  • To highlight DC characteristics that govern T cell responses in cancer.
  • To explore how DC functions can be leveraged for novel cancer immunotherapies.

Main Methods:

  • Review of existing scientific literature on dendritic cell biology and cancer immunology.
  • Analysis of the functional characteristics of DCs in the context of anti-tumour immunity.
  • Exploration of the link between DC functions and T cell-mediated therapies, including immune checkpoint blockade.

Main Results:

  • Dendritic cells are essential for instructing T cell immunity against cancer.
  • DC receptor repertoire and sensing capabilities contribute to anti-tumour CD8+ T cell induction.
  • DC functions are linked to enhanced responses to immune checkpoint blockade therapy.

Conclusions:

  • Dendritic cell biology provides key insights into cancer immunity.
  • Harnessing DC functions holds promise for developing improved cancer immunotherapies.
  • Further understanding of DCs can optimize T cell-based treatments for cancer patients.