Recent progress of dermal implants for aged skin rejuvenation: a review

Area of Science:

• Dermatology
• Biomaterials Science
• Regenerative Medicine

Background:

• Skin aging is a complex process involving reduced regeneration, inflammation, and increased disorder susceptibility.
• Intrinsic and extrinsic factors contribute to skin aging, with conventional treatments having limited efficacy.
• Dermal implants present a promising approach for skin rejuvenation due to enhanced delivery and prolonged effects.

Purpose of the Study:

• To systematically review recent advancements in implantable strategies for aged skin repair.
• To categorize and compare different types of dermal implants based on their properties and clinical performance.
• To highlight the potential of collagen-based implants in modulating inflammation and promoting skin remodeling.

Main Methods:

• Systematic review of implantable strategies for aged skin repair.
• Categorization of materials into inorganic fillers, synthetic polymers, hyaluronic acid-based, collagen-based, and composite implants.
• Critical comparison of structural properties, regenerative mechanisms, and clinical performances.

Main Results:

• Dermal implants offer enhanced bioavailability and prolonged therapeutic effects compared to conventional treatments.
• Collagen-based implants (hydrogels, fibers, microspheres) show significant potential in modulating inflammation and promoting endogenous collagen synthesis.
• Various implant types demonstrate different structural properties, regenerative mechanisms, and clinical outcomes.

Conclusions:

• Implantable strategies, particularly collagen-based ones, represent a significant advancement in treating aged skin.
• Collagen implants effectively modulate inflammation, stimulate collagen production, and facilitate dermal remodeling.
• Future research should focus on precision anti-aging therapies and commercialization of advanced dermal implant products.